And Aim. I forgot about Aim.
I'll update this post with any of the combos I've found especially useful.
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This is an awesome idea! I'll post some as soon as I get some time!
Alexander + Orbit
The skilled subset of the Orbit talismans are just a bonus
Building up on this, I've added a char with siege, Killer Beast with whatever, and Warrior Hierophant with Gate Talismans. One or two furys from KB, and as long as the enemy can't deal with your golden effects, they won't do damage to you. Made some farming increadibly safe, even with a low amount of relics.
If your character does "additional random damage based on [something]" and you can buff up whatever that [something] is with team synergy, then Chance talismans are very effective. From what I can tell, the critical chance is calculated on each "hit" of damage.