This is an absolutely insanely cool city to play. I really enjoyed my run through the dungeon. Sadly it turned out that i found a team as soon as i entered Hard that could complete any level all the way through Madness. Going through them again doing some of the skulls i missed i tried the final battle with only assassins. I hate to say it. But that was a huge dissapointment.
I do from time to time have a hard job defeating the beast on madness mode. But this one got destroyed with 4 hits.

I will not give away my team for the entire game-mode. But use the following if you have trouble with that last fight with only assasins:
Rainmaker Eddie (Advantage + Shadow), The Beast (Advantage + Shadow), Pyro Soldier (Energy + Endure (This 1 does not matter at all)).

Simply use the basic attack of Beast and Pyro + 6 Cost Special from Ed + Basic from Ed. And make them all perfect. And the boss dies.

Sad it ends so easy as it is really cool and the difficulty starts out really high. But it sort of stays the same on normal, hard and madness.