I'm using Alex Ed (orbits), Charlotte (viper, cosmic), KP (warlord, sustaining, cosmic, random green) and Lucifer (reaper, cosmic, random yellow) on manual. Eternity Eddie as a ride-along for the achievement. Keeping Gambler (angel, warlord, cosmic) in reserve if needed. About 2/3 there. Sometimes they go first. Had to revive a couple times. Rewards have included persecution talismans, talisman soul fragments, legendary souls, ironite, 500 ICs, keys and colored 3 star evo shards. I've only tried the Eternal Eddie battle.
Edit: I switched Lucifer to Dark Lilith (mark, sacred, cosmic echo) and it worked better. The marks worked well. Haven't had to revive since switching to Dark Lilith.