Yea I should mention that the Life Cosmic is vital for the Lilith Passive to kick in. I had not retested with Gunner LoL - Singularity since I switched out Hallowed as the Eddie. I will test more and find out. With Lillith in the first spot she tends to be the target of the Doom quite often but using Serenity on her would not allow for Inspiration which is key to phase 1 and 5. If you want to use another Eddie besides Hallowed I noticed that any Eddie with a Mark Cosmic will use that power ability more frequently than any of their normal powers and Marks do well across the whole run.
Gunner Angel of Mercy could also need some talisman tuning. Persecution were used prior to Hallowed to prevent the insane healing Warrior Minotaur in phase 1. I spent my first key learning so only had 1-2 wins in the hour and the current set up had 1 loss in the full hour. Still needs fine tuning but wanted to share what I had found so far.
Had also tried with Gunner Pharaoh Dog King for a blocker but the overall damage of the team was lacking.