Quote Originally Posted by dragonmat89 View Post
High Virtue Patience talisman makes the final wave doable (disables Wrathful). Not a help for the Assassin challenge but Max'ed Ancient Mariner is a great counter to the Soul talismans on wave 3 as he grants immunity to Ghost to all allies (most immunities only give it to Dark Ghost).
Quote Originally Posted by AndyCatzo View Post
you can also use osiris or brave talismans to gain protection against Ghost/Dark Ghost
Thank you both, these were just the tips I needed. By adding Brave and Patience talismans to the team I not only completed the Insanity Assassin challenge but was able to auto every run.

Full Assassin team was:

Max. Eternity Eddie (Archer, Burning, 3*Cosmic Past)
Max. Lilith Nightmoon (Justice, 5*Cosmic Alchemy)
Max. Mitsuko (Brave)
Sevastapol [Max. Assassin War Golem] (Prudence, 3*T2 Cosmic High Virtue - Patience + 1x random)

Fastest run was 2m45 but I suspect that swapping out Mitsuko for Musashi with Brave tali's would be a little faster as there were quite a few times where I was waiting for enemy defence effects to time out before completing the stage. Didn't try it though as I'd already spent ages failing and was just happy that I was finally progressing.