Just some tips for this one since some struggle here. You may not have access to these characters, but you might find something useful.
Here's what I use: Speed of Light Eddie, Alliance General, and twin green soulless demons. The general and SoL Eddie are typical builds, nothing special. I have blind sets on my soulless demons. Why? Because the blue Golden Sons can't heal if they can't hit you.
The first two rounds are fairly simple, use the green guys to kick butt. SoL Eddie can either heal, attack, or use the skill that blocks beneficial effects to block the Newborns from buffing.
The boss round: The blind effect won't take effect if you target the boss, since it can't affect the boss in any way. Activate the General's buff. The general and demons can then concentrate on damage, and SoL Eddie can heal or attack.
You used to be able to prevent ghosting on the boss by blocking beneficial effects, but it no longer works. You should still be able to end the ghost part by removing it or stealing the effect.
The general makes short work of the boss with his buff activated. The soulless demons do ok, but the talismans I have on them aren't up to snuff with the General. If you don't have these guys, find something else (preferably a green or non red) that can fit a blind set. If you don't have SoL Eddie, CR Eddie or something that has buff removal or steal capability.
Other useful debuffs are Bleeds and / or block healing, perma death, block revive. Hope that helps!