I don't definitely know the math, but I presume they work the same way as talismans.

Each relic adds what it says from the base stats, so for your example, global 46% and warrior 22%, a warrior with 1000 base health stat would have an additional 460 and 220 health, for total of 1680 health.
It's possible that it compounded, but I'd say unlikely since that's not how talismans work.