Nightmare talismans won't be cleansed so easily by Osiris if you had a character that could stand that long...oh and hit every player with it..
I just tried a bunch of different ideas including double the primordials, that didn't work, I can't use eclipse because Killer primes passive takes gold buffs away.. Same for immortals.. I did use My Gunner Mayan Priestess who is supposed revive with 60% hp but the permadeth negates that, even destiny's crumble against them. I have taken out Madam a couple of times and I survived an attack from start with DDE wearing shadow, useless... from that point though, Madam died at DDE's hands and I almost got Osiris but FFE made short work of me next turn...