some of the changes seem good: (first, only mentionning the characters i have)
Warrior COTD, Nomad, WDQ, Void talismans, death dog passive.

Some "nerfs" seem tricky.
Prisoners passive: well, it has been discussed big. I do not like it. Gotta see, how this works.

Others seem interesting:
Pharaoh, Mummy, troll, ascension talisman remodel.