My team does not change much and if it does just for speed but averages are all around the 20-30 second mark so no big deal.
Navigator (primeordial), GCOTD (Primordial), Prisoner (Primordial) and any other AoE hitter with a bit of a bang - Sentinal Harpy, Magus CR, Beelzebub, Gunner/Warrior/Assassin Lilith. Never have to wrry but I have got a fair number of relics as well on top of these being maxed and sharded.