I tell ya.... Scrooge Ed (Destiny) + Prince Wrath.... that last battle is won in the blink of an eye. Talismans aren't really that much of a factor although the Destiny on Scrooge is absolutely helpful. The other two can be your choice. W LOL with Orbits is a good call though.
I average around 40 sec runs and 99% of that is in the battles leading up to the last one.
Scrooge Ed removing buffs when attacked, then Wrath inflicting crave pretty much wipes out Lucifer before you ever attack anyone.