I've been running the required talisman sets on ride-along Mummy Eddie and Pharaoh Ramses. I've been running things the whole day with Soccer Eddie, Killer Prime, Necropolis and Maclo. Fastest time has been 1:06. Typical time under 2 minutes. I've been through it nearly 100 times thus far and have died twice. Don't forget that you can complete another challenge (achievement) by running Ascension talisman within Frontier Dungeons.

Copied from my post in response to Azagthor's. BTW--nice work both of you. I really appreciate your work!

Soccer with Valhalla and Ascension cosmic
Killer Prime with Reaper and Advantage
Necropolis with Viper and Life Cosmic
Maclo with Forge with Ascension Cosmic

I hope that helps someone, but many of the suggestions above seem like good ones.