I now have 3 primordial talismans and all have come from madness. I've given up on trying to farm on hard, seems you have to be very lucky to get any to drop from there. Only problem with running on madness is auto is really unreliable. DDE, Assassin Lilith, Alchemist and The Madam provides lots of healing and cleansing, as long as the Alchemist sticks to his basic or power skills more often than not. Which he doesn't do on auto....I've lost my assassin lilith and madam on occasion so have to go back from auto to manual around the last 2 waves to make sure I clear it. Total pain in the arse. But one more and I will just buy the remaining 2, this grinding is a joke. Night City better be really really good devs...