Hah, I've been running the C. General with Futures for some time now, and somehow it just never occurred to me to partner him with The Prisoner in Night City. I Just tried your idea on hard and was amazed at how much easier it became. With both the General and Breeg Eddie using Energy talismans and switching in Hallowed Eddie to help with stuns and accuracy, the enemies rarely even got to take a turn and had no power when they did!
I've considered getting Sekhmet for that reason, but I'm guessing that they'll be removing the extra turn from Eternity Eddie's revenge move or at least making it no longer guaranteed. But I've found that I can pull similar shenanigans by switching in Clansman Eddie, whose fury move also gives the whole team an extra turn. I think I'll spend my Frontier coins on either Horus or one of the Liliths. As for the demon spawn, that's another great idea I hadn't considered. Crave would be a perfect counter to those blue and green rollerskate sluts. Don't have Doomsday Eddie, but I probably have someone who can extend debuffs to help keep crave active.