Gold and Soul Vault Help

[Natasmai]

any idea how to solve it in auto run? which characters and talismans could be useful?

Think Yup found a way to auto it with IME, I've not managed it yet with any combos (and don't have IME) but can do it without ever goving the computer a turn through a team of IE, ADS, Prisoner, and then switching to Hallowed Eddie for the boss. Takes a couple of minutes

Benjamin Breeg has Angel and Guard
Killer Prime has Sustaining, Warlord and Inspiration
Prisoner has Primordials

It has failed once, but it works